GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs11976180 | 1 | rs2961117 | chr7:143755253 | ARHGEF35 | chr7:143883677-143892736:- | -0.32 | -5.45 | 9.0E-8 | Obesity-related traits |
| BLCA | cis | rs11976180 | 1 | rs2961118 | chr7:143755443 | ARHGEF35 | chr7:143883677-143892736:- | -0.34 | -5.97 | 5.56E-9 | Obesity-related traits |
| BLCA | cis | rs11976180 | 1 | rs2961119 | chr7:143755852 | ARHGEF35 | chr7:143883677-143892736:- | -0.34 | -6.05 | 3.43E-9 | Obesity-related traits |
| BLCA | cis | rs11976180 | 1 | rs2961120 | chr7:143756585 | ARHGEF35 | chr7:143883677-143892736:- | -0.34 | -6.06 | 3.26E-9 | Obesity-related traits |
| BLCA | cis | rs11976180 | 1 | rs2961125 | chr7:143761770 | ARHGEF35 | chr7:143883677-143892736:- | -0.34 | -6.06 | 3.3E-9 | Obesity-related traits |
| BLCA | cis | rs11976180 | 1 | rs2961126 | chr7:143762736 | ARHGEF35 | chr7:143883677-143892736:- | -0.34 | -6.06 | 3.3E-9 | Obesity-related traits |
| BLCA | cis | rs11976180 | 1 | rs2961128 | chr7:143763483 | ARHGEF35 | chr7:143883677-143892736:- | -0.34 | -6.06 | 3.3E-9 | Obesity-related traits |
| BLCA | cis | rs11976180 | 1 | rs2961132 | chr7:143768128 | ARHGEF35 | chr7:143883677-143892736:- | -0.32 | -5.55 | 5.33E-8 | Obesity-related traits |
| BLCA | cis | rs11976180 | 1 | rs2961134 | chr7:143771062 | ARHGEF35 | chr7:143883677-143892736:- | -0.34 | -6.04 | 3.67E-9 | Obesity-related traits |
| BLCA | cis | rs11976180 | 1 | rs2961144 | chr7:143747870 | ARHGEF35 | chr7:143883677-143892736:- | 0.33 | 5.85 | 1.07E-8 | Obesity-related traits |
| BLCA | cis | rs2905426 | 1 | rs2965188 | chr19:19522557 | YJEFN3 | chr19:19639720-19648393:+ | -0.23 | -4.44 | 1.16E-5 | Schizophrenia |
| BLCA | cis | rs2905426 | 1 | rs2965198 | chr19:19473030 | YJEFN3 | chr19:19639720-19648393:+ | 0.21 | 4.11 | 4.84E-5 | Schizophrenia |
| BLCA | cis | rs2294008 | 1 | rs2976388 | chr8:143760256 | LY6D | chr8:143866298-143868008:- | 0.25 | 5.07 | 6.08E-7 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |
| BLCA | cis | rs2294008 | 1 | rs2976388 | chr8:143760256 | PSCA | chr8:143761875-143764142:+ | 0.5 | 14.21 | 4.29E-37 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |
| BLCA | cis | rs2294008 | 1 | rs2976392 | chr8:143762932 | LY6D | chr8:143866298-143868008:- | 0.22 | 4.79 | 2.43E-6 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |